Identification and antifungal susceptibility of Candida species isolated from the urine of patients in a university hospital in Brazil

AUTOR(ES)

Lima, Gláucia Moreira Espíndola, Nunes, Maína de Oliveira, Chang, Marilene Rodrigues, Tsujisaki, Rosianne Assis de Sousa, Nunes, Joslaine de Oliveira, Taira, Cleison Ledesma, Thomaz, Danilo Yamamoto, Negro, Gilda Maria Bárbaro Del, Mendes, Rinaldo Pôncio, Paniago, Anamaria Mello Miranda

FONTE

Rev. Inst. Med. trop. S. Paulo

DATA DE PUBLICAÇÃO

21/12/2017

RESUMO

ABSTRACT The aim of this study was to identify Candida spp. isolated from candiduria episodes at a tertiary hospital in the Midwest region of Brazil, and to determine their susceptibility profiles to antifungal compounds. From May 2011 to April 2012, Candida spp. isolated from 106 adult patients with candiduria admitted to the University Hospital of the Federal University of Mato Grosso do Sul were evaluated. Both, species identification and susceptibility testing with fluconazole-FLC, voriconazole-VRC, and amphotericin B-AmB were carried out using the Vitek 2. To discriminate species of the C. parapsilosis complex, a RAPD-PCR technique using the RPO2 primer was performed. From the total of 106 isolates, 42 (39.6%) C. albicans and 64 (60.4%) Candida non-albicans (CNA) - 33 C. tropicalis, 18 C. glabrata, 5 C. krusei, 4 C. parapsilosis sensu stricto, 2 C. kefyr, 1 C. lusitaniae, and 1 C. guilliermondii were identified. All isolates were susceptible to AmB and VRC, whereas all C. glabrata isolates presented either resistance (5.6%) or dose-dependent susceptibility (94.4%) to FLC. The study of Candida spp. and their resistance profiles may help in tailoring more efficient therapeutic strategies for candiduria.

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