Identificação do padrão de metilação nos genes IFN- e IL-10 em polpa dental humana
AUTOR(ES)
Fabiano Pereira Cardoso
DATA DE PUBLICAÇÃO
2009
RESUMO
DNA methylation is characterized by addition of methyl groups in cytosines within CpG islands. Unmethylated islands are related with transcriptionally active structure, whereas methylated DNA recruits methyl-binding proteins that promotes chromatin compactation. Although epigenetic events can influence the expression of cytokines, it has not been already investigated in dental pulp. The purpose of the present study was to evaluate the methylation status of IFN- gene in human dental pulp affected by inflammation compared with pulp tissue cells of impacted molar teeth. The MSP was used to verify the DNA methylation status. While total methylation was only observed in some samples of the normal dental pulp tissues, partial methylation was found in most of the cases of inflamed pulp tissues. In conclusion, the present study gives the first evidence of the possible participation of epigenetic events in inflamed dental pulp.
ASSUNTO(S)
interferon gama decs polpa dentária teses interleucina-10 decs metilação decs pulpite decs.
ACESSO AO ARTIGO
http://hdl.handle.net/1843/ZMRO-836MUFDocumentos Relacionados
- Estudo da metilação nos genes IFN-y e IL-10 na doença periodontal
- Estudo do polimorfismo dos genes das citocinas TNFα, IFNγ, TGFβ, IL-6, E IL-10 em hansenÃase
- Increased levels of IL-10, IL-12, and IFN- in patients with visceral leishmaniasis
- Papel do IFN- e da iNOS na patogênese do dengue experimental
- Avaliação de IFN-γ e IL-10 em cães naturalmente infectados com Leishmania (Leishmania) chagasi com e sem manifestações clínicas