Hypolipidemic activity of friedelin isolated from Azima tetracantha in hyperlipidemic rats

AUTOR(ES)

Duraipandiyan, Veeramuthu, Al-Dhabi, Naif Abdullah, Irudayaraj, Santiagu Stephen, Sunil, Christudas

FONTE

Rev. bras. farmacogn.

DATA DE PUBLICAÇÃO

2016-02

RESUMO

Abstract The hypolipidemic activity of friedelin isolated from Azima tetracantha Lam., Salvadoraceae, was studied in Triton WR-1339 and high-fat diet-induced hyperlipidemic rats. In Triton WR-1339 induced hyperlipidemic rats, treatment with friedelin (50 and 70 mg/kg) showed a significant (p < 0.01) lipid-lowering effect as assessed by reversal of plasma levels of total cholesterol (TC), triacylglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). In high-fat diet fed hyperlipidemic rats, treatment with friedelin (50 and 70 mg/kg) caused lowering of lipid levels in plasma and liver. The hypolipidemic activity of friedelin was compared with fenofibrate, a known lipid-lowering drug, in both models.

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