Hydrophobic models of protein folding and the thermodynamics of chain-boundary interactions
AUTOR(ES)
Erzan, Ayse, Tüzel, Erkan
FONTE
Brazilian Journal of Physics
DATA DE PUBLICAÇÃO
2003-09
RESUMO
We review some results concerning the energetic and dynamical consequences of taking a generic hydrophobic model of a random polypeptide chain, where the effective hydrophobic interactions are represented by Hookean springs. Then we present a set of calculations on a microscopic model of hydrophobic interactions, investigating the behaviour of a hydrophobic chain in the vicinity of a hydrophobic boundary. We conclude with some speculations as to the thermodynamics of pre-biotic functions proteins may have discharged very early on in the evolutionary past.
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