Human Papillomavirus prevalence, viral load and cervical intraepithelial neoplasia in HIV-infected women

AUTOR(ES)

Levi, José E., Fink, Maria C.S., Canto, Cynthia L.M., Carretiero, Nadily, Matsubara, Regina, Linhares, Iara, Dores, Gérson B. das, Castelo, Adauto, Segurado, Aluísio, Uip, David E., Eluf Neto, José

FONTE

Brazilian Journal of Infectious Diseases

DATA DE PUBLICAÇÃO

2002-06

RESUMO

HIV-infected women from São Paulo city were enrolled in a cross-sectional study on Human Papillomavirus (HPV) and cervical intraepithelial neoplasia (CIN) prevalence and their association with laboratory markers of AIDS, namely HIV viral load and CD4+ cell counts. A cervical specimen was collected and submitted to Hybrid Capture, a test for HPV viral load determination. HPV-DNA was detected in 173 of 265 women (64.5%). Twenty (7.5%) women were infected by one or more low-risk viruses, 89 (33%) by one or more high-risk viruses, and 64 (24%) harbored at least one HPV type from each risk group. Abnormal smears were observed in 19% of the patients, though there were no invasive carcinomas. Severely immunosuppressed patients (CD4/µL <100) were at the greatest risk of having a cytological abnormality and a high high-risk HPV viral load.

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