Human papillomavirus detection and p16 methylation pattern in a case of esophageal papilloma

AUTOR(ES)

Afonso, L.A., Moysés, N., Cavalcanti, S.M.B.

FONTE

Brazilian Journal of Medical and Biological Research

DATA DE PUBLICAÇÃO

2010-07

RESUMO

Esophageal cancer is a prevalent cancer worldwide. Some studies have reported the possible etiology of human papillomavirus (HPV) in benign and malignant papillomas of the esophagus but the conclusions are controversial. In the present study, we investigated an esophageal papilloma from a 30-year-old male patient presenting aphasia. HPV DNA was detected by generic PCR using MY09/11 primers, and restriction fragment length polymorphism revealed the presence of HPV54, usually associated with benign genital lesions. Hypermethylation of the pINK4A gene was also investigated due to its relation to malignant transformation, but no modification was detected in the host gene. Except for an incipient reflux, no risk factors such as cigarette smoking, alcohol abuse or an infected sexual partner were recorded. Since esophageal lesions may have a malignant potential, HPV detection and typing are useful tools for patient follow-up.

Documentos Relacionados

• Inactivation of p16 in Human Mammary Epithelial Cells by CpG Island Methylation
• Methylation of p16 ink4a promoter is independent of human papillomavirus DNA physical state: a comparison between cervical pre-neoplastic and neoplastic samples
• Papilloma formation in human foreskin xenografts after inoculation of human papillomavirus type 16 DNA.
• Reversal of human cellular senescence: roles of the p53 and p16 pathways
• Conserved Methylation Patterns of Human Papillomavirus Type 16 DNA in Asymptomatic Infection and Cervical Neoplasia