Human alpha 1(III) and alpha 2(V) procollagen genes are located on the long arm of chromosome 2.
AUTOR(ES)
Emanuel, B S
RESUMO
The multigene procollagen family encodes probably greater than 20 genetically distinct but structurally related polypeptide chains. Recent characterization of human procollagen clones has allowed determination of functional domains within the proteins, genomic organization, and chromosomal location. Previously, we assigned the coordinately expressed type I genes (alpha 1 and alpha 2) to chromosomes 17 and 7, respectively, and now other investigators have mapped the type II gene to chromosome 12 [Strom, C. M., Eddy, R. L. & Shows, T. B. (1984) Somatic Cell Genet. 10, 651-655]. Recently, we isolated cDNA clones encoding the fourth interstitial procollagen, type III, and the alpha 2 chain of the type V cytoskeletal components. To determine whether these genes were clustered with alpha 1(I), alpha 2(I), or alpha 1(II) or were further dispersed in the genome, in situ hybridization of the alpha 1(III) and alpha 2(V) probes to metaphase chromosomes was carried out. Here we report a fourth autosome with procollagen gene loci but the first cytological evidence for linkage. By using normal and translocated cell lines, our results show that both the alpha 1(III) and alpha 2(V) procollagen genes map to the q24.3----q31 region of chromosome 2.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=397780Documentos Relacionados
- Two human c-onc genes are located on the long arm of chromosome 8.
- Human urokinase gene is located on the long arm of chromosome 10.
- Human collagen genes encoding basement membrane alpha 1 (IV) and alpha 2 (IV) chains map to the distal long arm of chromosome 13.
- Human type I procollagen genes are located on different chromosomes.
- Exclusion of the alpha 2(I) and alpha 1(III) collagen genes as the mutant loci in a Marfan syndrome family.