HPLC-MS profiling of the multidrug-resistance modifying resin glycoside content of Ipomoea alba seeds
AUTOR(ES)
Castañeda-Gómez, Jhon, Rosas-Ramírez, Daniel, Cruz-Morales, Sara, Fragoso-Serrano, Mabel, Pereda-Miranda, Rogelio
FONTE
Rev. bras. farmacogn.
DATA DE PUBLICAÇÃO
2017-08
RESUMO
ABSTRACT High performance liquid chromatography profiling with mass spectrometry detection was applicable to identify known and novel multidrug-resistance glycolipid inhibitors from the complex resin glycosides mixture of Ipomoea alba L., Convolvulaceae, seeds. Albinosides X and XI were purified by recycling liquid chromatography and their structural elucidation was accomplished by nuclear magnetic resonance. Albinoside XI exerted a strong potentiation of vinblastine susceptibility in multidrug-resistant human breast carcinoma cells.
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