How much hydration is necessary for the stabilisation of DNA-duplex?
AUTOR(ES)
Maltseva, T.V.
RESUMO
A combination of NOESY and ROESY experiments show that the higher stabilities (Tm) of phenazine tethered matched (2) and G-A mismatched (4) DNA duplexes are due to the decrease of the exchange-rate (i.e. increase of the life-time) of the imino-protons and the reduced water activity in their minor grooves compared to their non-tethered counterparts (1) and (3).
