Homologous ribosomal proteins in bacteria, yeast, and humans.

AUTOR(ES)

Chen, I T

RESUMO

We describe sequences of two human ribosomal proteins, S14 and S17, and messenger RNAs that encode them. cDNAs were used as molecular hybridization probes to recognize complementary genes in rodent, Drosophila, and yeast chromosomal DNAs. Human ribosomal protein sequences are compared to analogous Chinese hamster, yeast, and bacterial genes. Our observations suggest that some ribosomal protein genes have been conserved stringently in the several phylogenetic lines examined. These genes apparently were established early in evolution and encode products that are fundamental to the translational apparatus. Other ribosomal protein genes examined, although similar enough to heterologous DNA sequences to indicate their structural relationships, appear to have diverged substantially during evolution, probably reflecting adaptations to different genetic environments.

Documentos Relacionados

• Adherence of bacteria, yeast, blood cells, and latex spheres to large-porosity membrane filters.
• NAM9 nuclear suppressor of mitochondrial ochre mutations in Saccharomyces cerevisiae codes for a protein homologous to S4 ribosomal proteins from chloroplasts, bacteria, and eucaryotes.
• Homologous versus heterologous gene expression in the yeast, Saccharomyces cerevisiae.
• Identification of Candida lusitaniae as an opportunistic yeast in humans.
• Antisense overlapping open reading frames in genes from bacteria to humans.