Histomorphometric analysis of rabbits penis subjected to extracorporeal shockwaves therapy, in vivo study / Análise histomorfométrica do pênis de coelhos submetidos à terapia com ondas de choque, estudo in vivo

AUTOR(ES)
DATA DE PUBLICAÇÃO

2008

RESUMO

Introduction: Extracorporeal shockwaves (ESWL) have been proposed as a treatment for Peyronies disease. Objective: The aim of this study is to determine whether there is any injury to the normal penile tissue during ESWL in rabbits. Methods: 25 adult male NZW rabbits undergone to 3 sessions of ESWL . Divided into 3 groups: Group I(no shock) - 5 animals. Group II(Short-term effect) - 10 animals, sacrificed 7 days. Group III(Long-term effect) - 10 animals evaluated 90 days after the last session. The penile tissue was analyzed. Results: Macroscopically was observed the presence of hematomas, petechias and equimosis. Histological evaluation demonstrated the presence of basal cell degeneration, papilomathosis, acanthosis, congestion and fibrosis of the albuginea with increase of collagen fibers. Conclusion: ESWL produce injury in all tissues of the penis

ASSUNTO(S)

high-energy shock wave histological techniques técnicas histológicas coelhos penile induration ondas de choque de alta energia rabbits induração peniana colágeno collagen

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