Histologic study of corticosteroid injection in the acute vocal fold wound healing in a rabbit model / Estudo histológico da ação do corticosteróide injetável no processo agudo de cicatrização das pregas vocais de coelhos

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

Injectable corticosteroids have been used in phonosurgery to prevent scarring of the vocal fold due to their effects on wound healing, and to assure better voice quality. The aim of this study is to evaluate histologically the effects of dexamethasone infiltration on acute vocal fold wound healing in rabbits 3 and 7 days after surgically-induced injury, by quantification of the inflammatory reaction and collagen deposition. A standardized surgical incision was made in the vocal folds of 12 rabbits, and 0.1 ml dexamethasone (4 mg/ml) was injected into the left vocal fold. The right vocal fold was not injected and served as the control. The larynges were collected 3 and 7 days after surgery. For histological analysis, the vocal folds were stained with hematoxylin-eosin for quantification of the inflammatory response and with picrosirius red for quantification of collagen deposition. There was no quantitative difference in the inflammatory response between vocal folds injected with the corticosteroid and the control folds. However, collagen deposition was significantly lower in the corticosteroid-treated group at 3 and 7 days after the injury (p = 0.002). The present results suggest that dexamethasone reduces collagen deposition during acute vocal fold wound healing

ASSUNTO(S)

colágeno pregas vocais injectable corticosteroids cicatriz pregas vocais inflammatory reaction vocal fold scar collagen corticosteróides injetáveis reação inflamatória pregas vocais

ACESSO AO ARTIGO

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