High proliferative activity of Reed Sternberg associated antigen Ki-1 positive cells in normal lymphoid tissue.
AUTOR(ES)
Gerdes, J
RESUMO
An improved immunoenzymatic double labelling method was developed, which simultaneously shows the Ki-1 membrane antigen and the nuclear proliferation associated antigen, defined by monoclonal antibody Ki-67. This new approach permits in situ discrimination of cells that are proliferating or not with a particular membrane antigen. Most Ki-1 positive cells in normal lymphoid tissue also express the Ki-67 nuclear antigen and thus appear to be proliferating. As proliferating cells are more susceptible to malignant transformation than quiescent cells, it is possible that the small number of normal Ki-1 positive cells might, none the less, cause a large proportion of all lymphomas in man.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=500199Documentos Relacionados
- Ki-1 positive anaplastic large cell lymphoma of skin.
- Down-regulation of Epstein-Barr virus nuclear antigen 1 in Reed-Sternberg cells of Hodgkin's disease.
- Twelve cases of Ki-1 positive anaplastic large cell lymphoma of skin.
- Endogenous avidin-binding activity in human lymphoid tissue.
- Distribution of fibronectin and laminin in normal and pathological lymphoid tissue.