High prevalence of Borna disease virus infection in healthy sheep in Japan.
AUTOR(ES)
Hagiwara, K
RESUMO
Previous seroepidemiological and molecular epidemiological studies of Borna disease virus (BDV) showed considerably high rates of infection in horses, cattle, cats, and humans in Hokkaido, Japan. Here, we further demonstrate high rates of specific antibodies to BDV and BDV RNA in peripheral blood mononuclear cells (PBMCs) from healthy sheep bred on the same island. The BDV prevalences by immunoblotting and/or reverse transcriptase PCR were 0% (0 of 19) in newborns (<1 month old), 51.7% (15 of 29) in lambs (1 to 6 months old), and 36.7% (11 of 30) in adults (>2 years old). Among animals positive for BDV, 60% of lambs and 45.5% of adults contained BDV RNA in PBMCs while 46.7% of lambs and 90.9% of adults contained specific antibodies to BDV. Thus, it is suggested that virus replication in the blood, as observed in lambs, is usually reduced in adulthood by raising immune responses to BDV.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=170529Documentos Relacionados
- Demonstration of borna disease virus RNA in peripheral blood mononuclear cells derived from domestic cats in Japan.
- High prevalence of Neisseria gonorrhoeae strains with reduced susceptibility to fluoroquinolones in Japan.
- Prevalence of newly isolated, cytopathic small round virus (Aichi strain) in Japan.
- Prevalence of antibodies to Coxiella burnetii in Japan.
- Persistence of Borna Disease Virus in Naturally Infected Sheep