High encapsulation efficiency of sodium alendronate in eudragit S100/HPMC blend microparticles
AUTOR(ES)
Cruz, Letícia, Assumpção, Evelise, Guterres, Sílvia Stanisçuaski, Pohlmann, Adriana Raffin
FONTE
Química Nova
DATA DE PUBLICAÇÃO
2009
RESUMO
The hydrophilic drug sodium alendronate was encapsulated in blended microparticles of Eudragit® S100 and Methocel® F4M or Methocel® K100LV. Both formulations prepared by spray-drying showed spherical collapsed shape and smooth surface, encapsulation efficiencies of 85 and 82% and mean diameters of 11.7 and 8.4 µm, respectively. At pH 1.2, in vitro dissolution studies showed good gastro-resistance for both formulations. At pH 6.8, the sodium alendronate release from the microparticles was delayed and was controlled by Fickian diffusion. In conclusion, the prepared microparticles showed high encapsulation efficiency of sodium alendronate presenting gastro-resistance and sustained release suitable for its oral administration.
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