Hidden 19S IgM rheumatoid factor in adults with juvenile rheumatoid arthritis onset.
AUTOR(ES)
Speiser, J C
RESUMO
Forty-eight adult patients with juvenile rheumatoid arthritis (JRA) (onset before age 16 years) were evaluated at the age of 17 years or more for the presence of hidden 19S IgM rheumatoid factors (RF), i.e., 19S IgM RF that can be detected by the complement-dependent haemolytic assay in the IgM-containing fraction after separation of the serum by acid gel filtration. The average age of the patients was 25.3 years. The mean duration of disease was 16.5 years. Thirty-two of 48 patients (67%) showed the presence of hidden 19S IgM RF in their serum. Disease activity correlated with hidden RF titres in 62% (55/88) of the evaluations. The results indicate that patients with seronegative JRA onset continue to have significant titres of hidden 19S IgM RF in their sera into early adulthood.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1001634Documentos Relacionados
- Production of IgM rheumatoid factor by normal lymphocytes after stimulation with preparations containing IgM rheumatoid factor from patients with juvenile arthritis.
- Lack of hidden complement fixing IgM rheumatoid factor in adult seronegative rheumatoid arthritis.
- Production of 19S IgM Antibodies with Restricted Heterogeneity from Sharks
- Monomeric (7S) IgM found in the serum of rheumatoid arthritis patients share idiotypes with pentameric (19S) monoclonal rheumatoid factors.
- IgG, IgA, IgM, and IgD antiglobulins in juvenile rheumatoid arthritis.
