Hexose transport control in a fibroblast metabolic mutant can be promoted more effectively by D-allose than by glucose.

AUTOR(ES)

Ullrey, D B

RESUMO

By studying the energy-requiring control of the hexose transport system (the transport "curb") in a lung fibroblast mutant called the phosphoglucose isomerase mutant (because it is devoid of the enzyme phosphoglucose isomerase) the following features were noted. The aldohexose D-allose, if added over 20 hr to a culture of the mutant, promotes the development of an intense curb of the hexose transport system, greatly surpassing that brought about by incubation with glucose. The allose-mediated curb can be circumvented by various metabolic inhibitors as well as by the presence of other aldohexoses such as mannose.

Documentos Relacionados

• Tunicamycin tightens the glucose- and D-allose-mediated control of hexose transport in a metabolic fibroblast mutant.
• The D-allose operon of Escherichia coli K-12.
• d-Allose Catabolism of Escherichia coli: Involvement of alsI and Regulation of als Regulon Expression by Allose and Ribose
• Search for cellular phosphorylation products of D-allose.
• Concerted hexose transport curb by tunicamycin is rendered irreversible by glucose or allose in medium containing L-glutamine.