Heterogeneous trajectories in schizophrenia: insights from neurodevelopment and neuroprogression models
AUTOR(ES)
Reckziegel, Ramiro; Czepielewski, Letícia S.; Hasse-Sousa, Mathias; Martins, Dayane S.; de Britto, Maria J.; Lapa, Clara de O.; Schwartzhaupt, Alexandre W.; Gama, Clarissa S.
FONTE
Brazilian Journal of Psychiatry
DATA DE PUBLICAÇÃO
2022
RESUMO
The notion that schizophrenia is a neuroprogressive disorder is based on clinical perception of cumulative impairments over time and is supported by neuroimaging and biomarker research. Nevertheless, increasing evidence has indicated that schizophrenia first emerges as a neurodevelopmental disorder that could follow various pathways, some of them neuroprogressive. The objective of this review is to revisit basic research on cognitive processes and neuroimaging findings in a search for candidate keys to the intricate connections between neurodevelopment and neuroprogression in schizophrenia. In the complete panorama, schizophrenia is a neurodevelopmental disorder, possibly associated with an additional burden over the course of the disease through pathologically accelerated aging, and cognitive heterogeneity may explain the different trajectories of each patient.
