Herpesvirus-induced cell fusion that is dependent on cell surface heparan sulfate or soluble heparin.

AUTOR(ES)

Shieh, M T

RESUMO

The entry of enveloped viruses into animal cells and the cell-to-cell spread of infection via cell fusion require the membrane-fusing activity of viral glycoproteins. This activity can be dependent on variable cell factors or triggered by environmental factors. Here we show that cell fusion induced by herpes simplex virus glycoproteins is dependent on the presence of cell surface glycosaminoglycans, principally heparan sulfate, or on the addition of heparin to the medium. The role of the glycosaminoglycan is probably to alter the conformation of a viral heparin-binding glycoprotein required for the fusion.

Documentos Relacionados

• Marek's Disease Herpesvirus-Induced DNA Polymerase
• Preliminary biochemical characterization of the factors(s) responsible for herpesvirus-induced exogenous fusion.
• Independence of chicken major histocompatibility antigens and tumor-associated antigen on the surface of herpesvirus-induced lymphoma cells.
• Inhibition of Herpesvirus Replication and Herpesvirus-Induced Deoxyribonucleic Acid Polymerase by Phosphonoformate†
• Herpesvirus-induced "early" glycoprotein: characterization and possible role in immune cytolysis.