Herdabilidade dos fatores envolvidos na síndrome metabólica / The heritability of metabolic syndrome factors

AUTOR(ES)

Camila Maciel de Oliveira

DATA DE PUBLICAÇÃO

2007

RESUMO

Many studies have been conducted in different populations aiming at the identification of the proportion of total phenotypic variance that is attributable to genetic effects. The heritability of Metabolic Syndrome (MS) factors is expected to differ between populations because of the different distribution of environmental risk factors, as well as the genetic make-up of different human populations. The purpose of this analysis was to evaluate genetic and environmental influences on metabolic syndrome traits, using a variance component analysis, by estimating the heritability of these traits in a sample of extended pedigrees. We examined 1,712 individuals of 119 randomly selected families from the general population of a city of Brazil. A total of 1,666 individuals of 81 families were used for analysis. Family size varied from 3 to 156 individuals with a mean of 21 subjects per family. Before adjustment, polygenic heritability of systolic (SBP) and diastolic (DBP) blood pressure were 15% and 16.4%, waist circumference 26.1%, fasting glucose 32.8%, triglycerides 25.7%, and HDL-c 31.2%. Adjustment for age, sex, age2, age and sex interaction increased polygenic heritability estimates for all traits: SBP (25.9%), DBP (26.2%), waist circumference (40.1%), fasting glucose (34.5%), triglycerides (28.8%), and HDL-c (32,0%). When the Metabolic Syndrome factors were treated as discrete traits, using ATPIII cut off, the estimates of heritability after adjusting for covariates were: 24.5% for MS, 37.5% for blood pressure, 40.6% for abdominal circumference, 54.5% for fasting glucose, 25.5% for triglycerides, and 37.8% for HDL-cholesterol. In conclusion, heritability estimates for metabolic syndrome traits in a sample of Brazilian population are high and not significantly different from other studied worldwide populations

ASSUNTO(S)

genetics pressão arterial hereditariedade genetic predisposition to disease síndrome x metabólica blood pressure metabolic syndrome x predisposição genética para doença

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