Hepatitis C virus genotypes in blood donors from the Federal District, Central Brazil
AUTOR(ES)
Amorim, Regina MS, Oliveira, Claudiner P, Wyant, Patrícia S, Cerqueira, Daniela M, Câmara, Geni NL, Flores, Luciano S, Martins, Regina MB, Martins, Cláudia RF
FONTE
Memórias do Instituto Oswaldo Cruz
DATA DE PUBLICAÇÃO
2004-12
RESUMO
The objective of this study was to characterize hepatitis C virus (HCV) genotypes in blood donors from the Federal District, Central Brazil, and to compare HCV screening by serological assays and reverse transcriptase polymerase chain reaction (RT-PCR). Plasma samples from 57 individuals with reactive or indeterminate results in serological anti-HCV screening assays (ELISA or EIA) were tested for HCV RNA by RT-PCR. The results from a confirmatory LIA serological assay were also evaluated. The 5' non-coding region of the HCV genome was amplified from 41 PCR positive samples (71.9%), which were further characterized by nucleotide sequencing analysis. Of these, 60.9% were of HCV genotype 1 and 39.1% of genotype 3.
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