Hepatitis B e-antigen and its correlation with other serological markers in chimpanzees.

AUTOR(ES)

Ling, C M

RESUMO

Three chimpanzees experimentally infected with hepatitis B virus, and another three chimpanzees that were hepatitis surface antigen carriers, were studied for the presence of viral antigens and humoral immune responses. Quantitative analyses of hepatitis B surface and e-antigens in sequential serum samples at early acute stages revealed cyclic oscillations of these two antigens following a synchronous pattern. Similar analyses of anti-e-antigen and anti-hepatitis B core antigen antibodies from the three experimentally infected primates indicated that peak titers of these two antibodies occurred as surface antigen decreased to undetectable levels. Of the three surface-antigen carriers, two were positive for e-antigen and one was positive for e-antigen antibody for the entire course of surveillance (8, 9, and 22 months, respectively).

Documentos Relacionados

• Immunofluorescence of hepatitis A virus antigen in chimpanzees.
• delta Agent: association of delta antigen with hepatitis B surface antigen and RNA in serum of delta-infected chimpanzees.
• Hepatitis B virus produced by transfected Hep G2 cells causes hepatitis in chimpanzees.
• Chemically synthesized peptides of hepatitis B surface antigen duplicate the d/y specificities and induce subtype-specific antibodies in chimpanzees.
• Microbiological, serological, and histopathological features of experimental Chlamydia trachomatis urethritis in chimpanzees.