Heavy-Chain Variable Regions in Normal and Pathological Immunoglobulins

AUTOR(ES)

Wang, A. C.

RESUMO

Aminoacid sequence analysis of immunoglobulin G heavy chains from each of 15 normal individuals showed the presence of VHIII subgroup sequences in all individuals, to an extent of about 15-25% of the total. Therefore, different subgroups of the heavy-chain variable region are not products of alleles of a single gene.

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