gyrB mutations in coumermycin A1-resistant Borrelia burgdorferi.

AUTOR(ES)

Samuels, D S

RESUMO

We have isolated and characterized mutants of Borrelia burgdorferi that are resistant to the antibiotic coumermycin A1, which targets the B subunit of DNA gyrase. Mutants had either 100- or 300-fold higher resistance to coumermycin A1 than wild-type B. burgdorferi. In each case, a single point mutation in the gyrB gene converted Arg-133 to Gly or Ile. Mutations in the homologous Arg residue of Escherichia coli DNA gyrase are also associated with resistance to coumarin antimicrobial agents.

Documentos Relacionados

• GyrB mutations in Staphylococcus aureus strains resistant to cyclothialidine, coumermycin, and novobiocin.
• Mutations in Bartonella bacilliformis gyrB Confer Resistance to Coumermycin A1
• groEL Expression in gyrB Mutants of Borrelia burgdorferi
• gyrA and gyrB mutations in quinolone-resistant strains of Escherichia coli.
• Genetic transformation of the Lyme disease agent Borrelia burgdorferi with coumarin-resistant gyrB.