Guanylate cyclase activity in normal and diseased human muscle.
AUTOR(ES)
Cerri, C
RESUMO
Guanylate cyclase activity has been studied in muscle of normal subjects and of patients suffering from muscular and neuromuscular diseases. In normal tissue a guanylate cyclase activity was found in both soluble and particulate fractions of homogenate. We found also that the kinetic analysis of the enzyme of soluble differed from that of particulate fraction. A decrease of guanylate cyclase activity in crude homogenate was observed in muscular dystrophies, in neuromuscular atrophies, and in inflammatory forms of muscle disease.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=493158Documentos Relacionados
- Atrial natriuretic factor elicits an endothelium-independent relaxation and activates particulate guanylate cyclase in vascular smooth muscle.
- Guanylate cyclase activity in Escherichia coli mutants defective in adenylate cyclase.
- Purified Clostridium difficile cytotoxin stimulates guanylate cyclase activity and inhibits adenylate cyclase activity.
- Differentiation of spontaneous activity from normal and denervated skeletal muscle.
- Testosterone and its precursors and metabolites enhance guanylate cyclase activity.