Growth of Cryptococcus neoformans Within Human Macrophages In Vitro
AUTOR(ES)
Diamond, Richard D.
RESUMO
Macrophages cultured from human peripheral blood monocytes were infected with Cryptococcus neoformans in vitro. Although C. neoformans were actively ingested, there was no detectable intracellular killing by macrophages. Over 2 days or more, intracellular fungi grew more rapidly than a corresponding inoculum of extracellular cryptococci growing in tissue culture medium containing human serum. Macrophages were induced to develop into cells which appeared to be activated by morphological and phagocytic criteria. However, these activated cells did not acquire an ability to kill or inhibit intracellular growth of C. neoformans. There were no detectable differences between macrophages from normal subjects and those from cryptococcosis patients.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=422665Documentos Relacionados
- Superoxide Dismutase Influences the Virulence of Cryptococcus neoformans by Affecting Growth within Macrophages
- Cryptococcus neoformans Resides in an Acidic Phagolysosome of Human Macrophages
- Phagocytosis of Cryptococcus neoformans by alveolar macrophages.
- Opsonization of Cryptococcus neoformans by human immunoglobulin G: role of immunoglobulin G in phagocytosis by macrophages.
- Phenotypic and functional characterization of human lymphocytes activated by interleukin-2 to directly inhibit growth of Cryptococcus neoformans in vitro.
