Group B streptococcal type Ia sepsis in mice after intranasal inoculation and the effect of infection on lungs.
AUTOR(ES)
Wennerstrom, D E
RESUMO
The intranasal inoculation of adult mice with saline suspensions of virulent group B streptococci serotype Ia resulted in septicemia which was lethal. Decreasing the inoculation dose of streptotocci increased the time required for their appearance in the blood and the mean time to death of the mice. Before the appearance of septicemia, the number of organisms in the lungs decreased to about 1% of the inoculation dose, and the majority could be recovered by lavage of the lungs through the trachea. In contrast, most of the organisms remained in the lavaged lungs of bacteremic mice after intranasal or intravenous inoculation. Lung surfactant obtained from infected mice was altered by a reduction in lipid and by an increase in protein. The organisms in vitro did not attack surfactant lipid labeled with [1-14C]palmitic acid, but their pathogenesis in vivo affected the permeability of the air-blood barrier, as shown by the leakage into the air spaces of plasma albumin labeled by the intravenous injection of Evans blue dye.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=414609Documentos Relacionados
- Mucin model for group B type III streptococcal infection in mice.
- Intranasal Immunization of Mice with Group B Streptococcal Protein Rib and Cholera Toxin B Subunit Confers Protection against Lethal Infection
- Antimicrobial Therapy of Experimental Group B Streptococcal Infection in Mice
- Effect of chlorphentermine on the lipids of rat lungs.
- Immunochemistry of purified polysaccharide type antigens of group B streptococcal types Ia, Ib, and Ic.