Gestacional protein restriction triggers hiperanxiety in adulthood due to changes in the bed nucleus of stria the terminalis (BNST) / Avaliação de parâmetros comportamentais e da estrutura tridimensional de neurônios do núcleo da estria terminal de ratos machos adultos expostos à restrição protéica gestacional

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

27/01/2012

RESUMO

In developed and developing countries maternal and child malnutrition has obvious repercussions on the population health f. This is due to changes in ontogenetic development, linked to the manifestation of programmed changes in morphological and functional development of organs and systems. The fetal programming by malnutrition or protein deficiency leads to increased fetal exposure to maternal glucocorticoids and alters the function of postnatal hippocampal-hypothalamic-pituitary-adrenal axis that may result in chronically increased exposure to glucocorticoids (GC) or exacerbated stress response in adults. The BNST is located in a key position to regulate stress response and has been implicated in anxiety behavior. Evidence suggests that this brain region is highly plastic and responsive to deleterious stimuli in terms of neuronal morphology...Note: The complete abstract is available with the full electronic document.

ASSUNTO(S)

glicocorticoides ansiedade feto - desenvolvimento glucocorticoids anxiety fetal development

ACESSO AO ARTIGO

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