Genotype-Environment Interaction: Apolipoprotein E (Apoe) Gene Effects and Age as an Index of Time and Spatial Context in the Human
AUTOR(ES)
Zerba, K. E.
RESUMO
We analyzed the age-dependence of the estimates of the parameters of the genetic architecture of plasma ApoE levels associated with ApoE gene variation. Our study sample included 1988 individuals in multigeneration pedigrees from the Rochester, MN, population. We used a 30-yr sliding window across the age range (5-90 yr) to estimate the age dependency of parameters. Additive ApoE allelic variance of transformed plasma ApoE values for both genders, heritabilities for males and phenotypic and residual variance for females peaked in the 20-40-yr age windows and decreased significantly with age (P < 0.05). Phenotypic and residual variance for males and dominance variance for both genders did not vary significantly with age. All parameter estimates were significantly different from zero across all age windows for both genders. Most studies of ApoE have focused on its functions in the pathophysiology of coronary artery disease (CAD) in middle-aged and older individuals. Our findings suggest the greatest role of this gene is in determining phenotypic differences among younger and middle-aged individuals. These observed genotypic effects on the plasma ApoE levels may contribute to age-dependent differences in physiological health, growth, and risk of disease.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1207278Documentos Relacionados
- Additive-Multiplicative Approximation of Genotype-Environment Interaction
- Prediction of Hevea progeny performance in the presence of genotype-environment interaction
- Genotype-Environment Interactions: A Reply
- Multiplicative Genotype-Environment Interaction as a Cause of Reversed Response to Directional Selection
- Genotype-Environment Interactions and the Maintenance of Polygenic Variation