Genomic imprinting proposed as a surveillance mechanism for chromosome loss.

AUTOR(ES)

Thomas, J H

RESUMO

One consequence of genomic imprinting is that loss of the transcriptionally active chromosomal homologue causes a change in gene expression that might permit surveillance of chromosome-loss events. Possible selective advantages of such surveillance include protection against cancer and early elimination of monosomic and trisomic fetuses. Potential mechanisms for such surveillance are discussed.

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