Genome-wide gene expression profiles of the developing mouse hippocampus
AUTOR(ES)
Mody, Monica
FONTE
The National Academy of Sciences
RESUMO
We have analyzed the developmental molecular programs of the mouse hippocampus, a cortical structure critical for learning and memory, by means of large-scale DNA microarray techniques. Of 11,000 genes and expressed sequence tags examined, 1,926 showed dynamic changes during hippocampal development from embryonic day 16 to postnatal day 30. Gene-cluster analysis was used to group these genes into 16 distinct clusters with striking patterns that appear to correlate with major developmental hallmarks and cellular events. These include genes involved in neuronal proliferation, differentiation, and synapse formation. A complete list of the transcriptional changes has been compiled into a comprehensive gene profile database (http://BrainGenomics.Princeton.edu), which should prove valuable in advancing our understanding of the molecular and genetic programs underlying both the development and the functions of the mammalian brain.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=37526Documentos Relacionados
- Genome-wide analysis of developmental and sex-regulated gene expression profiles in Caenorhabditis elegans
- Genome-Wide Analysis of Spatial Gene Expression in Arabidopsis FlowersW⃞
- Sister grouping of chimpanzees and humans as revealed by genome-wide phylogenetic analysis of brain gene expression profiles
- Cross-species comparison of genome-wide expression patterns
- Genome-wide analysis of mRNA translation profiles in Saccharomyces cerevisiae
