Genome-Wide Analysis of the Biology of Stress Responses through Heat Shock Transcription Factor
AUTOR(ES)
Hahn, Ji-Sook
FONTE
American Society for Microbiology
RESUMO
Heat shock transcription factor (HSF) and the promoter heat shock element (HSE) are among the most highly conserved transcriptional regulatory elements in nature. HSF mediates the transcriptional response of eukaryotic cells to heat, infection and inflammation, pharmacological agents, and other stresses. While HSF is essential for cell viability in Saccharomyces cerevisiae, oogenesis and early development in Drosophila melanogaster, extended life span in Caenorhabditis elegans, and extraembryonic development and stress resistance in mammals, little is known about its full range of biological target genes. We used whole-genome analyses to identify virtually all of the direct transcriptional targets of yeast HSF, representing nearly 3% of the genomic loci. The majority of the identified loci are heat-inducibly bound by yeast HSF, and the target genes encode proteins that have a broad range of biological functions including protein folding and degradation, energy generation, protein trafficking, maintenance of cell integrity, small molecule transport, cell signaling, and transcription. This genome-wide identification of HSF target genes provides novel insights into the role of HSF in growth, development, disease, and aging and in the complex metabolic reprogramming that occurs in all cells in response to stress.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=419887Documentos Relacionados
- The Role of Heat Shock Transcription Factor 1 in the Genome-wide Regulation of the Mammalian Heat Shock ResponseD⃞
- A genome-wide analysis of immune responses in Drosophila
- Genome-Wide ORFeome Cloning and Analysis of Arabidopsis Transcription Factor Genes1[w]
- Uncovering the complexities of Kaposi's sarcoma through genome-wide expression analysis
- Genome-wide Responses to Mitochondrial DysfunctionV⃞