Genetic transmission of colorectal cancer: exploratory data analysis from a population based registry.
AUTOR(ES)
Ponz de Leon, M
RESUMO
Classical segregation analysis was conducted on 605 families of probands with colorectal carcinoma ascertained through the Cancer Registry of the Province of Modena in Italy. The families were classified as 28 suspected hereditary non-polyposis colorectal cancer (HNPCC) syndromes and 577 presumed non-HNPCC. In 11 of these, both parents had colorectal carcinoma, in 130 one parent was affected, and in 436 both parents were normal. In the suspected HNPCC families, segregation was compatible with dominant transmission of susceptibility to carcinoma. In families with one parent affected, the segregation frequency was almost exactly equal to the frequency of segregation in families where both parents were normal. The model of dominant transmission of susceptibility through a major gene with greatly reduced penetrance in heterozygotes fitted the data acceptably.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1016056Documentos Relacionados
- Importance of district of residence and known primary site for bowel cancer survival: analysis of data from Wessex Cancer Registry.
- Cancer risks in painters: study based on the New Zealand Cancer Registry.
- Reliability of data of the Thames cancer registry on 673 cases of colorectal cancer: effect of the registration process.
- General practitioners and completeness of cancer registry.
- Screening for colorectal cancer: a general-practice-based study.
