Genetic Structure Adds Power to Detect Schizophrenia Susceptibility at SLIT3 in the Chinese Han Population
AUTOR(ES)
Shi, YongYong
FONTE
Cold Spring Harbor Laboratory Press
RESUMO
The Chinese Han population, the largest population in the world, has traditionally been geographically divided into two parts, the Southern Han and Northern Han. In practice, however, these commonly used ethnic labels are both insufficient and inaccurate as descriptors of inferred genetic clustering, and can lead to the observation of “spurious association” as well as the concealment of real association. In this study, we attempted to address this problem by using 14 microsatellite markers to reconstruct the population genetic structure in 768 Han Chinese samples, including 384 Southern Han and 384 Northern Han, and in samples from Chinese minorities including 48 Yao and 48 BouYei subjects. Furthermore, with a dense set of markers around the region 5q34–35, we built fine-scale haplotype networks for each population/subpopulation and tested for association to schizophrenia susceptibility. We found that more variants in SLIT3 tend to associate with schizophrenia susceptibility in the genetically structured samples, compared to geographically structured samples and samples without identified population substructure. Our results imply that identifying the hidden genetic substructure adds power when detecting association, and suggest that SLIT3 or a nearby gene is associated with schizophrenia.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=442150Documentos Relacionados
- Association between the g.296596G > A genetic variant of RELN gene and susceptibility to autism in a Chinese Han population
- Association between the c.910A>G genetic variant of the XRCC1 gene and susceptibility to esophageal cancer in the Chinese Han population
- A genetic model for a central (septum transversum) congenital diaphragmatic hernia in mice lacking Slit3
- Schizophrenia is not associated with the ERBB3 gene in a Han Chinese population sample: results from case-control and family-based studies
- Repulsive axon guidance molecule Slit3 is a novel angiogenic factor