Genetic recombination of human immunodeficiency virus.
AUTOR(ES)
Clavel, F
RESUMO
We investigated genetic recombination of the human immunodeficiency virus (HIV) in a tissue culture system. A clonal cell line expressing a single integrated HIV provirus with a termination codon affecting pol gene expression was transfected with different defective mutants derived from an infectious molecular clone of HIV. Replication-competent viral particles were recovered, passaged, and plaque purified. Restriction analyses of the proviral DNA corresponding to several of these viruses indicated that their emergence was the result of genetic recombination.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=247851Documentos Relacionados
- Genetic regulation of human immunodeficiency virus.
- The Remarkable Frequency of Human Immunodeficiency Virus Type 1 Genetic Recombination
- Quantifying the infectivity of human immunodeficiency virus.
- Development of vivo of genetic variability of simian immunodeficiency virus.
- Generation of human monoclonal antibodies to human immunodeficiency virus.
