Genetic linkage map of human chromosome 7 with 63 DNA markers.
AUTOR(ES)
Barker, D
RESUMO
High-density genetic maps of individual human chromosomes will permit accurate localization of disease-associated genes and provide signposts that will be useful in the construction of physical maps. We have constructed a genetic map of chromosome 7 with 63 polymorphic DNA markers by using segregation data from 23 three-generation families and recently developed multilocus linkage-analysis techniques. The map spans 250 centimorgans in females and 170 centimorgans in males, with much of the difference being concentrated in a few intervals. The density and informativeness of the markers are such that there is a high probability of detecting linkage to any disease gene on this chromosome for which 20 phase-known meioses are available.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=299465Documentos Relacionados
- Genetic linkage map of 46 DNA markers on human chromosome 16.
- Genetic analysis with random amplified polymorphic DNA markers.
- Genetic linkage maps of 'Pêra' sweet orange and 'Cravo' mandarin with RAPD markers.
- Genetic markers on chromosome 7.
- A Genetic Linkage Map of Mouse Chromosome 10: Localization of Eighteen Molecular Markers Using a Single Interspecific Backcross