Genetic Control of Phosphate-Metabolizing Enzymes in NEUROSPORA CRASSA: Relationships among Regulatory Mutations
Littlewood, Barbara S.
In Neurospora crassa, the phosphate-metabolizing enzymes are made during phosphate starvation, but not under phosphate sufficiency. The synthesis of these enzymes is controlled by three regulatory genes: pcon-nuc-2, preg and nuc-1. pcon-nuc-2 and preg are closely linked. A model of the hierarchical relationships among these regulatory genes is presented. Studies of double mutants and revertants confirm several predictions of the model. It has been found that nuc-2 (null) and pconc (constitutive) mutations reside in the same cistron. pregc (constitutive) mutations are epistatic to nuc-2 mutations. nuc-1 (null) mutations are epistatic to all others.
ACESSO AO ARTIGOhttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1213282
- Pyrimidine Synthesis in Neurospora crassa: Gene-Enzyme Relationships
- Circadian Rhythms in NEUROSPORA CRASSA: Interactions between Clock Mutations
- Genetic interactions between clock mutations in Neurospora crassa: can they help us to understand complexity?
- Genetic Control of Phosphorus Assimilation in NEUROSPORA CRASSA: Dose-Dependent Dominance and Recessiveness in Constitutive Mutants
- Genetic Control of Heterocaryosis in Neurospora Crassa