Genetic characterization of dengue virus type 3 isolates in the State of Rio de Janeiro, 2001

AUTOR(ES)

Miagostovich, M.P., Santos, F.B. dos, Simone, T.S. de, Costa, E.V., Filippis, A.M.B., Schatzmayr, H.G., Nogueira, R.M.R.

FONTE

Braz J Med Biol Res

DATA DE PUBLICAÇÃO

2002-08

RESUMO

The genetic characterization of dengue virus type 3 (DEN-3) strains isolated from autochthonous cases in the State of Rio de Janeiro, Brazil, in 2001 is presented. Restriction site-specific (RSS)-PCR performed on 22 strains classified the Brazilian DEN-3 viruses as subtype C, a subtype that contains viruses from Sri Lanka, India, Africa and recent isolates from Central America. Nucleic acid sequencing (positions 278 to 2550) of one DEN-3 strain confirmed the origin of these strains, since genotype III - classified by sequencing - and RSS-PCR subtype C are correlated. This genetic subtype has been associated with hemorrhagic dengue epidemics and the information provided here could be useful to implement appropriate prevention and control measures.

Documentos Relacionados

• Dengue virus type 3 in Rio de Janeiro, Brazil
• A epidemia de dengue/dengue hemorrágico no município do Rio de Janeiro, 2001/2002
• Dengue virus type 3 isolation from Aedes aegypti in the municipality of Nova Iguaçu, State of Rio de Janeiro
• Comparative immunological recognition of proteins from New Guinea "C" dengue virus type 2 prototype and from a dengue virus type 2 strain isolated in the State of Rio de Janeiro, Brazil
• Pathologic study of a fatal case of dengue-3 virus infection in Rio de Janeiro, Brazil