Gene therapy for established murine collagen-induced arthritis by local and systemic adenovirus-mediated delivery of interleukin-4
AUTOR(ES)
Kim, Seon Hee
FONTE
BioMed Central
RESUMO
To determine whether IL-4 is therapeutic in treating established experimental arthritis, a recombinant adenovirus carrying the gene that encodes murine IL-4 (Ad-mIL-4) was used for periarticular injection into the ankle joints into mice with established collagen-induced arthritis (CIA). Periarticular injection of Ad-mIL-4 resulted in a reduction in the severity of arthritis and joint swelling compared with saline- and adenoviral control groups. Local expression of IL-4 also reduced macroscopic signs of joint inflammation and bone erosion. Moreover, injection of Ad-mIL-4 into the hind ankle joints resulted in a decrease in disease severity in the untreated front paws. Systemic delivery of murine IL-4 by intravenous injection of Ad-mIL-4 resulted in a significant reduction in the severity of early-stage arthritis.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=17812Documentos Relacionados
- Protection against cartilage and bone destruction by systemic interleukin-4 treatment in established murine type II collagen-induced arthritis
- Antigen-specific T cell–mediated gene therapy in collagen-induced arthritis
- Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma.
- Anti-C5 monoclonal antibody therapy prevents collagen-induced arthritis and ameliorates established disease.
- Suppression of murine collagen-induced arthritis by targeted apoptosis of synovial neovasculature
