Gender-specific association of the rs6499640 polymorphism in the FTO gene with plasma lipid levels in Chinese children
AUTOR(ES)
Gao, Liwang, Wu, Lijun, Zhang, Meixian, Zhao, Xiaoyuan, Cheng, Hong, Mi, Jie
FONTE
Genet. Mol. Biol.
DATA DE PUBLICAÇÃO
04/06/2018
RESUMO
Abstract The fat mass- and obesity-associated gene (FTO) is significantly associated with obesity, but the associations of FTO with obesity-related traits are not fully described. We aimed to investigate the association of the FTO single nucleotide polymorphism (SNP) rs6499640 with lipid levels in Chinese children. A total of 3503 children aged 6-18 years were included in the present study. Lipid levels were analyzed and the SNP rs6499640 was genotyped using the TaqMan Allelic Discrimination Assay. Statistically significant associations were found between rs6499640 and low-density lipoprotein cholesterol (LDL-C) (p = 0.008), total cholesterol (TC) (p = 0.005), and triglycerides (TG) (p < 0.001) in girls under a dominant model adjusted for age and BMI. No statistical significance was found between the SNP and lipid levels in boys. We demonstrated for the first time that the SNP rs6499640 in FTO is associated with LDL-C, TC, and TG in Chinese girls. Our study identified a new risk locus for lipid levels in children.
Documentos Relacionados
- Gender-specific Associations Between Soy and Risk of Hip Fracture in the Singapore Chinese Health Study
- Gender-specific risk factors for gout: a systematic review of cohort studies
- Effect of concurrent training on gender-specific biochemical variables and adiposity in obese adolescents
- Ageing and telomeres: a study into organ- and gender-specific telomere shortening
- Gender-Specific Mental and Behavioral Outcomes Among Physically Abused High-Risk Seventh-Grade Youths