Gêmeos monozigóticos discordantes para transexualidade : diferenças neuroanatômicas e psicológicas






The present work is an exploratory study case that discusses about neuroanatomical, hormonal and neuropsychological factors and their possible associations in one monozygotic male twin pair discordant for transsexualism. Both twins answered semi-structural interviews applied by specialized team from Gender Identity Disorder Program of Hospital de Clínicas de Porto Alegre, Brazil; In addition, they were tested with the Wechsler Adult Intelligence Scale (WAIS) battery that evaluate verbal and non verbal cognitive functions that contribute to general intelligence; and underwent magnetic resonance imaging (MRI) to measure the volumes of specific cerebral structures. The mother of the twins gave information (father did not want to participate) about the pregnancy, delivery, conditions of birth, childhood, raising environment, unusual medical or life history events. Both neuroimaging and cognitive function testing detected different outcome between the twins. In six different cerebral regions differences have been found in the volume of specific structures, as well as in language, visuo-spatial abilities. It is suggested that epigenetic factors could be related to the phenotypic discordance and the findings of this study


transsexualism transexualismo identidade de gênero gender identity disorder transtornos sexuais e de identidade sexual twins monozygotic gêmeos monozigóticos testes psicológicos magnetic resonance imaging psychological tests

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