Fuzzy modeling to predict the risk of recurrence and progression of superficial bladder tumors / Modelagem fuzzy para predizer os riscos de recidiva e progressão de tumores superficiais de bexiga

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

Nowadays, the bladder cancer is the fourth most common cancer in adults and the second most frequent urogenital tumor. Predicting recurrence and progression of superficial bladder tumors, with available clinical information to decide the therapy to be used is hard work. In this work, two mathematical models were developed to help specialist on the decision process. The tool used to developed these models was the fuzzy sets theory, by it capacity in dealing with uncertainties inherent in medical concepts. In the first model, Stage, Grade and Size of tumor had been considered input variables and Risk of Recurrence of a superficial bladder tumor as output variable of the first Fuzzy Rule-Based Systems (FRBS). In the second model, in addition to the Stage, Grade and Size of the tumor, also was considered as input variable of a second FRBS Carcinoma in situ and as a output variable, the Risk of Progression of superficial tumors. For each model, simulations were made with data of patients of the Clinics Hospital/UNICAMP and A. C. Camargo Hospital of São Paulo, with the aim to verify the reliability of results generated by the two systems. From a database and possibility found by FRBS, after the possibility-probability transformation, we can generate the real case probability of each fuzzy output set.

ASSUNTO(S)

biomathematics modelos matematicos mathematical models cancer biomatematica conjuntos difusos fuzzy sets cancer - modelos matemáticos

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