Fungal Lethality, Binding, and Cytotoxicity of Syringomycin-E
AUTOR(ES)
De Lucca, A. J.
FONTE
American Society for Microbiology
RESUMO
Syringomycin-E (SE) was significantly lethal to Aspergillus and Fusarium species at between 1.9 and 7.8 μg/ml. SE complexed with the following fungal wall constituents (in order of binding): β-1,3-glucan > chitin > mannan > ergosterol = cholesterol. Cytotoxicity in HeLa cells was proportional to the SE concentration, while the amount required for cytotoxicity was 3 to 20 times that needed to kill 95% of the fungi tested.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=89081Documentos Relacionados
- Pathogenesis, Lethality, and Immunizing Effect of Experimental Cutaneous Cryptococcosis
- µ1A-adaptin-deficient mice: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors
- Neonatal Lethality, Dwarfism, and Abnormal Brain Development in Dmbx1 Mutant Mice
- Effects of Shiga Toxin 2 on Lethality, Fetuses, Delivery, and Puerperal Behavior in Pregnant Mice
- Femoral fractures in the elderly in Brasil - incidence, lethality, and costs (2008-2018)