Functional Roles of Human Kallikrein-related Peptidases*
AUTOR(ES)
Sotiropoulou, Georgia
FONTE
American Society for Biochemistry and Molecular Biology
RESUMO
Kallikrein-related peptidases constitute a single family of 15 (chymo)trypsin-like proteases (KLK1–15) with pleiotropic physiological roles. Aberrant regulation of KLKs has been associated with diverse diseases such as hypertension, renal dysfunction, skin disorders, inflammation, neurodegeneration, and cancer. Recent studies suggested that coordinated activation and regulation of KLK activity are achieved via a complex network of interactions referred to as the “KLK activome.” However, it remains to be validated whether these hypothetical KLK activation cascade pathways are operative in vivo. In addition, KLKs have emerged as versatile signaling molecules. In summary, KLKs represent attractive biomarkers for clinical applications and potential therapeutic targets for common human pathologies.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2785139Documentos Relacionados
- The use of kallikrein-related peptidases as adjuvant prognostic markers in colorectal cancer
- Physiological Roles of Pneumococcal Peptidases
- Activation of Human Factor VII in Plasma and in Purified Systems: ROLES OF ACTIVATED FACTOR IX, KALLIKREIN, AND ACTIVATED FACTOR XII
- Inhibitors of Kallikrein in Human Plasma
- Inactivation of kallikrein in human plasma.
