From lymphocytes to sharks: V(D)J recombinase moves to the germline
AUTOR(ES)
Roth, David B
FONTE
BioMed Central
RESUMO
The antigen-receptor genes of vertebrates are rearranged by a specialized somatic recombination mechanism in developing lymphocytes - and, unexpectedly, also in the germline of cartilaginous fishes. The recombination system that carries out these DNA rearrangements may thus be a significant evolutionary force, perhaps not limited to rearrangements at antigen-receptor loci.
