Fine structure and morphogenesis of spironolactone bodies in the zona glomerulosa of the human adrenal cortex
AUTOR(ES)
Kovacs, K.
RESUMO
Numerous spironolactone bodies have been detected in the zona glomerulosa cells of the adrenal cortex of a 36-year-old spironolactone-treated woman whose non-tumorous right adrenal gland was removed surgically because of primary hyperaldosteronism. Electron microscopy revealed spherical laminated whorls which consisted of a central core composed of an amorphous electron-dense material surrounded by numerous smooth-walled concentric membranes. Continuous with and deriving from the endoplasmic reticulum, they were present in viable cells and were not associated with ultrastructural features indicating cellular injury. Cytoplasmic inclusions similar to spironolactone bodies can be detected in other organs after the administration of various compounds. Thus, they can be regarded as neither specific to spironolactone treatment nor exclusively inducible in the zona glomerulosa of the adrenal cortex.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=477936Documentos Relacionados
- Endothelin binding to cultured calf adrenal zona glomerulosa cells and stimulation of aldosterone secretion.
- Evidence for extracellular, but not intracellular, generation of angiotensin II in the rat adrenal zona glomerulosa.
- Mitochondrial structure in the rat adrenal cortex.
- A stereological study of the trophic effects of the renin-angiotensin system on the rat adrenal zona glomerulosa.
- Fine Structure and Morphogenesis of Borna Disease Virus