Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless
AUTOR(ES)
Min, Hosung
FONTE
Cold Spring Harbor Laboratory Press
RESUMO
Fgf-10-deficient mice (Fgf-10−/−) were generated to determine the role(s) of Fgf-10 in vertebrate development. Limb bud initiation was abolished in Fgf-10−/− mice. Strikingly, Fgf-10−/− fetuses continued to develop until birth, despite the complete absence of both fore- and hindlimbs. Fgf-10 is necessary for apical ectodermal ridge (AER) formation and acts epistatically upstream of Fgf-8, the earliest known AER marker in mice. Fgf-10−/− mice exhibited perinatal lethality associated with complete absence of lungs. Although tracheal development was normal, main-stem bronchial formation, as well as all subsequent pulmonary branching morphogenesis, was completely disrupted. The pulmonary phenotype of Fgf-10−/− mice is strikingly similar to that of the Drosophila mutant branchless, an Fgf homolog.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=317210Documentos Relacionados
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