Ferulate Anion Intercalated into Zn/Al Layered Double Hydroxide: A Promising Intercalation Compound for Inhibition of Leishmania (L.) amazonensis

AUTOR(ES)

Sousa, Robson

FONTE

J. Braz. Chem. Soc.

DATA DE PUBLICAÇÃO

23/05/2019

RESUMO

Ferulic acid (FERH) is known to exert leishmanicidal action against Leishmania (Leishmania) amazonensis. In this study, the ferulate anion (FER–) was intercalated into a layered double hydroxide (LDH) for FER– delivery during an antileishmania in vitro test. The LDH-FER– intercalation compound was prepared by coprecipitation and was characterized by X-ray powder diffraction, thermogravimetry, UV-Vis, infrared, and Raman spectroscopy analyses. Leishmania (L.) amazonensisin vitro assays were conducted to assess the LDH-FER– potential. LDH-FER– was found to promote a dose-dependent reduction of L. (L.) amazonensis amastigotes (intracellular form, half maximal inhibitory concentration (IC50) = 1.78 µg mL-1) without exerting a deleterious effect on the host macrophages (medium cytotoxic concentration (CC50) = 212.61 µg mL-1 and selectivity index = 119.4). LDH-FER– was found to be an effective inhibitor of the amastigote form of L. (L.) amazonensis, suggesting that LDH-FER– was able to deliver FER– inside the parasitophorous vacuoles where the pH is more acidic.

Documentos Relacionados

• Intercalation of Molybdate Ions into Ni/Zn Layered Double Hydroxide Salts: Synthesis, Characterization, and Preliminary Catalytic Activity in Methyl Transesterification of Soybean Oil
• Intercalation of Apocarotenoids from Annatto (Bixa orellana L.) into Layered Double Hydroxides
• Zinc layered hydroxide salts: intercalation and incorporation into low-density polyethylene
• New Alternative to Produce Colored Polymer Nanocomposites: Organophilic Ni/Al and Co/Al Layered Double Hydroxide as Fillers into Low-Density Polyethylene
• Identificação e isolamento de proteinas que se ligam aos telomeros de Leishmania (L.) amazonensis