Ferrous iron uptake by a magnesium transport system is toxic for Escherichia coli and Salmonella typhimurium.

AUTOR(ES)

Hantke, K

RESUMO

At low magnesium concentrations, Escherichia coli and Salmonella typhimurium LT2 accumulate ferrous iron independent of the ferrous iron transport system feo. Mutant strains with mutations in the magnesium transport gene corA accumulated less ferrous iron than the parent strains. corA+ and corA strains also differed in their sensitivity to ferrous iron under oxic conditions. corA mutants were more resistant to ferrous iron than their parent corA+ strains. Part of the ferrous iron accumulated can be chased by the addition of magnesium. Much less iron was chased when ferric iron was taken up by the siderophore ferrichrome. These results may indicate that the intracellular metabolism of the iron taken up by these systems differs and that it depends on the uptake route of the iron.

Documentos Relacionados

• Characterization of the ferrous iron uptake system of Escherichia coli.
• Structure and function of the uhp genes for the sugar phosphate transport system in Escherichia coli and Salmonella typhimurium.
• Thujaplicins from Thuja plicata as iron transport agents for Salmonella typhimurium.
• Activity of the nicotinamide mononucleotide transport system is regulated in Salmonella typhimurium.
• Activation of a new proline transport system in Salmonella typhimurium.