Fc gamma RI and Fc gamma RIII on polymorphonuclear leucocytes in cord blood.
AUTOR(ES)
Takahashi, N
RESUMO
Fc gamma RI and Fc gamma RIII expression on polymorphonuclear leucocytes in cord blood from seven normal infants was investigated by flow cytometry. Fc gamma R expression on fresh polymorphonuclear leucocytes in whole blood samples and in blood samples incubated with or without interferon gamma (IFN-gamma) for 48 hours was also studied. The percentage of Fc gamma RIII positive polymorphonuclear leucocytes in cord blood (73.3%) was significantly lower than that in adult controls (95.9%). The mean fluorescence intensity of Fc gamma RIII was significantly increased on cord polymorphonuclear leucocytes by the incubation with IFN-gamma. Fresh cord polymorphonuclear leucocytes expressed only a small amount of Fc gamma RI as adult polymorphonuclear leucocytes. The percentage of Fc gamma RI positive polymorphonuclear leucocytes induced with IFN-gamma was significantly higher in cord blood (62.3%) than in adult controls (30.3%). It is possible that decreased expression of Fc gamma RIII is a factor in the susceptibility of newborns to infection. High expression of Fc gamma RI stimulated with IFN-gamma in neonates could have a compensatory role against decreased immunological function.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1060984Documentos Relacionados
- Absence of Fc epsilonRI alpha chain results in upregulation of Fc gammaRIII-dependent mast cell degranulation and anaphylaxis. Evidence of competition between Fc epsilonRI and Fc gammaRIII for limiting amounts of FcR beta and gamma chains.
- Altered expression of Fc gammaRIII (CD16) on polymorphonuclear neutrophils from individuals with human immunodeficiency virus type 1 disease and pulmonary tuberculosis.
- Signalling through neutrophil Fc gamma RIII, Fc gamma RII, and CD59 is not impaired in active rheumatoid arthritis.
- Role of associated gamma-chain in tyrosine kinase activation via murine Fc gamma RIII.
- An Fc gamma RII-, Fc gamma RIII-specific monoclonal antibody (2.4G2) decreases acute Trypanosoma cruzi infection in mice.
